B.1.1.529 escapes the majority of SARS-CoV-2 neutralizing antibodies of 2 diverse epitopes

4. Yunlong Cao1,2,#,*, Jing Wang1,3,#, Fanchong Jian1,4,#, Tianhe Xiao1,5,#, Weiliang

5. 5  Song1,3,#, Ayijiang Yisimayi1,3,#, Weijin Huang6,#, Qianqian Li6, Peng Wang1,

6. 6  Ran An1, Jing Wang1, Yao Wang1, Xiao Niu1,4, Sijie Yang1,7, Hui Liang1, Haiyan

7. 7  Sun1, Tao Li6, Yuanling Yu6, Qianqian Cui6, Shuo Liu6, Xiaodong Yang8, Shuo

8. 8  Du3, Zhiying Zhang3, Xiaohua Hao9, Fei Shao1, Ronghua Jin9, Xiangxi Wang10,*,

9. 9  Junyu Xiao2,3,*, Youchun Wang6,*, Xiaoliang Sunney Xie1,2,*

10

11. 11  1Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing,

12. 12  P.R. China.

13. 13  2Beijing Advanced Innovation Center for Genomics (ICG), Peking University,

14. 14  Beijing, P.R. China.

15. 15  3School of Life Sciences, Peking University, Beijing, P.R. China.

16. 16  4College of Chemistry and Molecular Engineering, Peking University, Beijing,

17. 17  P.R. China.

18. 18  5Joint Graduate Program of Peking-Tsinghua-NIBS, Academy for Advanced

19. 19  Interdisciplinary Studies, Peking University, Beijing, China.

20. 20  6Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for

21. 21  Biological Product Control, National Institutes for Food and Drug Control

22. 22  (NIFDC), and WHO Collaborating Center for Standardization and Evaluation of

23. 23  Biologicals, Beijing, P.R. China.

24. 24  7Tsinghua-Peking Center for Life Sciences, Beijing, P.R. China.

25. 25  8Beijing YouAn Hospital, Capital Medical University, Beijing, P.R. China.

26. 26  9Beijing Ditan Hospital, Capital Medical University, Beijing, P.R. China.

27. 27  10CAS Key Laboratory of Infection and Immunity, National Laboratory of

28. 28  Macromolecules, Institute of Biophysics, Chinese Academy of Sciences,

29. 29  Beijing, P.R. China.

30. 30  *Correspondence: Yunlong Cao (yunlongcao@pku.edu.cn); Junyu Xiao

31. 31  (junyuxiao@pku.edu.cn); Xiangxi Wang (xiangxi@ibp.ac.cn); Youchun Wang

32. 32  (wangyc@nifdc.org.cn); Xiaoliang Sunney Xie (sunneyxie@biopic.pku.edu.cn)

33. 33  #These authors contributed equally.