DISIALOGANGLIOSIDE GD3 (NH4+ SALT), BOVINE BUTTERMILK

SPECIFICATIONS

• Catalog #:1504
• Scientific Name:Disialoganglioside GD₃ (NH₄⁺ salt)
• Common Name:GD₃
• Empirical Formula:C₇₅H₁₃₅N₃O₂₉•2NH₃ (tricosanoyl)
  Typical fatty acid content
• CAS#:62010-37-1
• SDS:View Safety Data Sheet
• Data Sheet:View Data Sheet
• Formula Weight:1543+2NH₃ (tricosanoyl)
• Unit:5 mg
• Source:natural
• Purity:98+%
• Analytical Methods:TLC,identity confirmed by MS
• Natural Source:bovine buttermilk
• Solubility:chloroform/methanol, 2:1; forms micellar solution in water
• Physical Appearance:solid
• Storage:-20°C
• Dry Ice:No
• Hazardous:No

• DESCRIPTION

  Application Notes:

  Gangliosides¹ are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.² They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. GD₃ is predominantly expressed during neuronal development and its expression becomes very limited in adult tissues. GD₃ expression is unusually high in basal cell carcinomas and malignant melanomas and is thought to be a human melanoma-specific antigen. Although GD₃ is not immunogenic it has been investigated as a tool for immunotargeting human melanoma cells.³ Over expression of GD₃ has led to apoptosis by recruiting mitochondria to apoptotic pathways and suppressing NF-κB activation and subsequent κB-dependent gene induction.⁴ Increased levels of GD₃ have also been found to be associated with proliferative diseases, such as atherosclerosis.

  References:
  1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
  2. T. Kolter, R. Proia, K. Sandhoff, J. Biol. Chem., Vol. 277:29 pp. 25859-25862, 2002
  3. H. Jennings et al., Journal of Biological Chemistry, Vol. 279:24 pp. 25390, 2004
  4. J. Fernández-Checa et al., Journal of Biological Chemistry, Vol. 277:51 pp. 49870, 2002