TG 在免疫方向的研究
台湾成功大学医学院朱 教授等人通过对比缺失 KitW-sh/W-sh 与野生型皮肤感染 DENV（登革热病毒）的小鼠出血时间，得出 mast cell-macro-phage（肥大巨噬细胞）在 DENV 病毒感染中能够作为免疫调节剂。该文章 发 表 在 2015 年 7 Immunology 杂志上。
The skin inoculation site sections were stained with anti-rabbit IgG (red) antibody and nuclei were stained with hematoxylin (blue). Thestaining images were quantified by HistoQuest software. Red arrows indicate F4/80-positive macrophages and CCL2 (MCP-1)-positive cells. (Magnification: x200) (b, d) The F4/80-positive macrophages and CCL2 (MCP-1)-positive cells were counted in 15 regions per mouse field and the average numbers of macrophages and CCL2 (MCP-1)-positive cells were calculated by HistoQuest software.
Compared with WT mice, KitW-sh/W-sh mice show enhanced DENV infection and macrophage infiltration at the skin inoculation site as well as increased DENV-associated bleeding time. The results indicate an intriguing interplay between mast cells and tissue macro-phages to restrict DENV replication
