凝血酶原片段 1+2 - 血栓性疾病早期诊断分子标志物
凝血酶原片段 1+2 是凝血酶原激活转化为凝血酶过程中释放的稳定的降解产物，血液中的凝血酶原片段 1+2 含量可以准确地反映凝血酶早期激活水平，可用于诊断血栓前状态和血栓性疾病以及针对相关疾病及时治疗和监测疗效。
以人凝血酶原片段 1+2 为例，当凝血途径启动，凝血因子 X 被激活转变为 Xa，Xa 可促使凝血酶原中 Arg(327)-Thr(328) 及 Arg(363)-Ile(364) 间的肽键同时断裂，释放凝血酶及凝血酶原片段 1+2，即 Ala(44)-Arg(327)。该凝血酶能够裂解酶原本身，释放出片段 1（F1）和片段 2（F2），序列分别为 Ala(44)-Arg(198)， Ser(199)-Arg(327)（见图 1）。
凝血酶原片段 1+2 的研究已经从实验走向临床， Cloud-Clone Corp. 针对此片段研制了一系列产品，对于实验室科研客户推出了引物对，重组蛋白，特异性抗体和免疫检测试剂盒等科研产品，工业级客户推出了抗体对以及 DIY 试剂盒产品，以及针对临床研究客户的 IVD 原料产品，产品列表如下，欢迎需求的客户咨询及选购。
| CATALOG NO. | ORGANISM SPECIES | PRODUCT NAME | APPLICATIONS | |
| Increment Service | PGA710 Hu01 | Homo sapiens (Human) | Primer Pair for Prothrombin Fragment 1+2 (F1+2) | PCR |
| PGA710Mu01 | Mus musculus (Mouse) | Primer Pair for Prothrombin Fragment 1+2 (F1+2) | PCR | |
| PGA710Ra01 | Rattus norvegicus (Rat) | Primer Pair for Prothrombin Fragment 1+2 (F1+2) | PCR | |
| Proteins | RPA710 Hu01 | Homo sapiens (Human) | Recombinant Prothrombin Fragment 1+2 (F1+2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA710Mu01 | Mus musculus (Mouse) | Recombinant Prothrombin Fragment 1+2 (F1+2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA710Ra01 | Rattus norvegicus (Rat) | Recombinant Prothrombin Fragment 1+2 (F1+2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA710 Hu01 | Homo sapiens (Human) | Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC; IP. |
| LAA710 Hu71 | Homo sapiens (Human) | Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC. | |
| MAA710 Hu21 | Homo sapiens (Human) | Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC; IP. | |
| LAA710 Hu72 | Homo sapiens (Human) | Biotin-Linked Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC. | |
| PAA710Mu01 | Mus musculus (Mouse) | Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC; IP. | |
| PAA710Ra01 | Rattus norvegicus (Rat) | Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC; IP. | |
| LAA710Ra81 | Rattus norvegicus (Rat) | FITC-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC; IF. | |
| LAA710Ra71 | Rattus norvegicus (Rat) | Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) | WB; IHC; ICC. | |
| Assay Kits | SEA710 Hu | Homo sapiens (Human) | ELISA Kit for Prothrombin Fragment 1+2 (F1+2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA710 Hu | Homo sapiens (Human) | CLIA Kit for Prothrombin Fragment 1+2 (F1+2) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEA710 Hu | Homo sapiens (Human) | High Sensitive ELISA Kit for Prothrombin Fragment 1+2 (F1+2) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEA710Mu | Mus musculus (Mouse) | ELISA Kit for Prothrombin Fragment 1+2 (F1+2) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SCA710Ra | Rattus norvegicus (Rat) | CLIA Kit for Prothrombin Fragment 1+2 (F1+2) | Chemiluminescent immunoassay for Antigen Detection. | |
| SEA710Ra | Rattus norvegicus (Rat) | ELISA Kit for Prothrombin Fragment 1+2 (F1+2) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEA710Po | Sus scrofa; Porcine (Pig) | ELISA Kit for Prothrombin Fragment 1+2 (F1+2) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| Antibody Pairs | PSA710 Hu01 | Homo sapiens (Human) | Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1) | ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays. |
| PSA710Mu01 | Mus musculus (Mouse) | Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1) | ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays. | |
| PSA710Ra01 | Rattus norvegicus (Rat) | Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1) | ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays. | |
| PSA710Po01 | Sus scrofa; Porcine (Pig) | Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1) | ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays. | |
| Assay Kit DIY Materials | KSA710 Hu01 | Homo sapiens (Human) | ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2) | Main materials for "Do It(ELISA Kit) Yourself" |
| KSA710Mu01 | Mus musculus (Mouse) | ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2) | Main materials for "Do It(ELISA Kit) Yourself" | |
| KSA710Ra01 | Rattus norvegicus (Rat) | ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2) | Main materials for "Do It(ELISA Kit) Yourself" | |
| KSA710Po01 | Sus scrofa; Porcine (Pig) | ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2) | Main materials for "Do It(ELISA Kit) Yourself" | |
| IVD Raw Materials | RSA710 Hu21 | Homo sapiens (Human) | Anti-Prothrombin Fragment 1+2 (F1+2) Monoclonal Antibody for IVD Raw Material | ELISA; WB; IHC; Other Immunoassays. |
| RSA710 Hu01 | Homo sapiens (Human) | Anti-Prothrombin Fragment 1+2 (F1+2) Polyclonal Antibody for IVD Raw Material | ELISA; WB; IHC; Other Immunoassays. |
表 1 凝血酶原片段 1+2 系列产品
武汉云克隆科技股份有限公司及其下属武汉优尔生商贸有限公司、武汉优尔生生命科学装备有限公司、武汉云克隆动物有限公司和武汉云克隆诊断试剂研究所坐落于武汉经济技术开发区，是以分子生物学与免疫学研究和实验发展为主的高新技术企业集团。CLOUD-CLONE CORP. (CCC, USA) 位于休斯敦，是「Cloud-Clone」的商标持有人。公司主营业务集中于检测试剂制备、分析仪器制造和动物实验服务。
股份公司已整体通过 ISO 9001:2008、ISO 13485:2003 质量管理体系认证，以提供生命科学科研用检测试剂为主，75% 以上的服务对象位于欧美国家。
武汉云克隆科技股份有限公司
地址：武汉经济技术开发区出口加工区
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