Adaptation of Corning® HepatoCells for 3D Spheroid Culture and Hepatotoxicity Studies
Introduction
• In vitro hepatic 3D cultures are known to better reflect the in vivo behaviors of liver cells; Industry is paying
increasing attention to 3D in vitro systems.
• Corning® HepatoCells (Cat. No. 354881) are a renewable hepatic cell source derived from primary human
hepatocytes with consistent phenotypes, drug metabolism enzyme/transporter activities.
• Adaptation of HepatoCells to spheroid culture (96-well or 384-well format) and tests with classic liver toxins
demonstrate the applications of HepatoCells for ADME research and liver cytotoxicity studies.
