TOYOPEARL HW products are hydroxylated methacrylic polymer resins. TOYOPEARL HW beads are made commercially in many different pore sizes and particle diameters (30 micron and larger).
They vary from TSKgel PW beads by having a lower degree of crosslinking. Lower crosslinking makes available a larger number of resin sites for ligand immobilization when producing TOYOPEARL HW based ion exchange and hydrophobic interaction chromatography resins.
Therefore a functionalized TOYOPEARL HW resin will have a higher dynamic binding capacity than the corresponding TSKgel PW material.
Because similarly functionalized HW and PW resin types have the same backbone polymer chemistry, the selectivity for proteins and impurities remains the same.
TOYOPEARL HW based resin products can be used at high linear velocities and withstand operating pressures up to 3 bar.